Homeless and Addiction Recovery Treatment Hubs HART Hubs: Reference Document, January 2025

The expanding pharmaceutical sector and international partnerships are facilitating access to innovative therapies. Challenges such as limited healthcare resources are being addressed through policy reforms and investments in diagnostic facilities. The focus on expanding treatment options and clinical research is expected to accelerate market growth, making Pakistan an emerging hub for pancreatic and bile duct cancer therapeutics in the region. Anonymous online marketplaces are usually platforms for sellers and buyers to conduct transactions in a virtual environment. They usually come with anonymous forums for sellers and buyers to share information, promote their products, leave feedback, and share experiences about purchases.

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The expanding pharmaceutical sector and government initiatives to improve cancer care infrastructure are crucial factors. Additionally, the growing prevalence of these cancers among the aging population is expected to boost demand for advanced therapeutics. Market players are increasingly focusing on local collaborations and clinical research to enhance treatment options tailored to regional patient needs. The opioid buyer (client) will also access the anonymous online market and create an account in each anonymous marketplace before they can find the listings of opioids (step 4). After perusing the items available on the anonymous online market (step 5), the buyer will add opioids to their shopping cart (step 6). When the buyer wants to check out and make a purchase using cryptocurrency (eg, Bitcoin), if the trader accepts payment through an anonymous online marketplace as an escrow, the buyer will place the listed amount of cryptocurrency in escrow (step 7).

• We will post updates regarding extended downtime, security incidents, or migration notices.
• In this way, we collected 7100 promotion posts and 6408 review posts from forum posts in total.
• The expanding pharmaceutical sector and government initiatives to improve cancer care infrastructure are crucial factors.
• Bookmark this clearnet page (drughub.io) and the official onion address.
• Among other services, this offering continues today and is a cornerstone service of many hubs.
• Law enforcement agencies around the world seized an online marketplace and arrested nearly 300 people allegedly involved in buying and selling drugs, European Union law enforcement agency Europol said Tuesday.
• Most recently, Swiss pharma behemoth Novartis unveiled plans to build a new radioligand therapy manufacturing facility in Winter Park, Florida, as part of a $23 billion U.S. investment pledge announced in April 2025.
• Phishing sites with similar addresses are common in the darknet ecosystem.

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Once the item is received, the buyer finalizes the purchase by notifying the anonymous online marketplace to release the funds held in escrow (step 11) [8,9]. After that, an opioid buyer often leaves review comments under the product listing or discusses the purchasing experience in the forum (step 12). The global market for pancreatic and bile duct cancer therapeutics is experiencing significant growth driven by advancements in targeted therapies, increasing prevalence of these cancers, and expanding research initiatives. The rising adoption of personalized medicine and innovative drug delivery systems further contribute to market expansion. Emerging markets are showing promising potential due to improving healthcare infrastructure and heightened awareness.

• M&A activities help companies expand capabilities, market reach, and competitive positioning.
• Stay informed about the latest darknet marketplaces, secure browsing practices, and privacy tools.
• Nontraditional methods, as presented here by studying the online supply chain, present a novel approach for governmental and other large-scale solutions.
• In addition, J&J kicked off 2026 by announcing plans to build a next-generation cell therapy manufacturing site in Pennsylvania.

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The metadata revealed not only the tools used but hinted at the environment in which the logo was crafted. Mac OS, a favorite among creative professionals, appeared to be the operating drughub.su system of choice. But what could have been a mere quirk of a designer’s preference quickly escalated into a glaring oversight, setting off alarm bells among cybersecurity experts.

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To better understand the potential bundling relationship of opioid suppliers across different marketplaces, we calculated the Jaccard similarity coefficient between the suppliers in different marketplaces (Figure 6). We found that 182 opioid supplier IDs appeared in both the marketplaces Evolution and Agora from January 2014 to July 2015. In particular, we observed that 84 opioid supplier IDs synchronized similar product listings in both marketplaces at the same time. This might be because the suppliers tend to promote their products across various marketplaces and to increase sales.

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We then analyzed these forum posts to profile underground opioid trading behaviors. It is comprehensive but accessible and policy-oriented, intended to facilitate discussions at EU-level on how to respond to darknet drug markets, whilst identifying key priority areas that require attention and where activities are likely to have most impact. Minister of Health Sylvia Jones has said the government plans to open 19 of the treatment hubs and 375 highly supportive housing units at a planned cost of $378 million. The hubs will not provide a safe supply of illicit drugs, supervised consumption services or needle exchange programs.

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Each year, Frost & Sullivan presents this award to the company that has developed a product with innovative features and functionality that is gaining rapid acceptance in the market. The award recognizes the quality of the solution and the customer value enhancements it enables. Regulations influence product standards, sustainability compliance, and market entry strategies. M&A activities help companies expand capabilities, market reach, and competitive positioning.

Pakistan Pancreatic And Bile Duct Cancer Market characteristics

Then, the trader receives the order and escrow confirmation (step 8). Otherwise, the buyer will pay the trader directly using cryptocurrency or any other payment method accepted by the trader (step 9) [7]. Note that the escrow mechanism is widely deployed in the anonymous online market because it helps to build trust and resolve disputes between sellers and buyers. When the purchase is made, the opioid trader ships the purchased item to the buyer (step 10).

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The hub vendor specifically services this patient set and works diligently to resolve problems, thereby boosting compliance and preventing abandonment. Specialty pharmacy providers (SPPs) are working to gain access to limited distribution medications and service patients to the best of their ability, but it is patients who can end up as victims to all of these complexities. We are a pan-Canadian collective of harm reductionists, drug policy activists, and people who use(d) drugs. These trends are likely to continue, as online marketplaces become more sophisticated and more people turn to e-commerce outlets to score their illegal products.

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These background papers were commissioned by the EMCDDA and Europol to provide background information to inform and contribute to the drafting of the main report. The EMCDDA and Europol are very grateful for the valuable contribution of the author. The papers have been cited within the report and are also being made available here for those who would like further information on the topic. However, the views, interpretations and conclusions set out in this publication are those of the author and are not necessarily those of the EMCDDA, Europol or their partners, any EU Member State or any agency or institution of the European Union.

On the way home, they made some side stops to pick up drugs and got high and drunk together. These shadow operators have been romanticized in Hollywood films that present them in the archetype of the rugged frontiersman and cowboy who does what is necessary to defeat the nation’s evil, and invariably, dark-skinned foes. Perhaps most shocking was the discovery of 212 forged travel documents, including 130 international passports. The suspects, all of whom have prior records, have been referred to the prosecutor. The 55-year-old owner was arrested last week for allegedly sourcing drugs from a 76-year-old Palestinian national.

Sri Lanka Pancreatic And Bile Duct Cancer Market data and reports

Figures 2 and 3 illustrate examples of opioid listings in The Versus Project and Alphabay. The opioid trader will also use an anonymous online forum (eg, The Hub Forum) to post promotional information to attract potential customers (step 3). Our study used opioid keywords and jargons to recognize listings and forum traces related to underground opioid trading activities. Our opioid jargon identification procedure implemented a modified semantic comparison model [19]. This model employed a neural network–based embedding technique to analyze the semantics of words in different corpora. In particular, in the semantic comparison model, the size of the input layer was doubled while not expanding either the hidden or the output layer.

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The decision to operate clearnet mirrors alongside Tor-hidden services compounded the problem. While clearnet mirrors can provide redundancy and accessibility, they also expose the platform to the scrutiny of law enforcement agencies. In DrugHub’s case, the risks were amplified by its server’s geographical location and its choice of hosting providers.

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• Among them, suboxone and subutex medicines are most frequently mentioned by 2917 times in listings and traces in 10 platforms, followed by roxy series (ie, roxy, roxi, roxies, and roxys) with 2022 times and Lean with 1256 times.
• Frost & Sullivan Best Practices Awards recognize companies in various regional and global markets for demonstrating outstanding achievement and superior performance in leadership, technological innovation, customer service, and strategic product development.
• One of the principal purposes of the hub is to ensure patient compliance and prevent therapy abandonment.
• That gap also worries advocates who are imploring Premier Ford to change his mind about closing down supervised consumption sites, warning drug problems will become more visible and more fatal — even with new funding — if he does not.
• The Asia-Pacific region is projected to register the fastest growth, propelled by rapid industrialization, expanding manufacturing capacity, urban development, and increasing uptake of cost-effective technologies across China, India, and Southeast Asian economies.
• By navigating financial and logistical barriers, these services ensure patients have easier access to critical, high-cost medications.
• This can occur when benefits investigation is ongoing or when a servicing pharmacy is no longer in network.

Hence, every word has 2 vectors, each describing the word’s relations with other words in one corpus. In the meantime, these 2 vectors are still comparable because they are used together in the neural network to train a single skip-gram model for predicting the surrounding windows of context words. We trained the semantic comparison model using the traces of Reddit as the benign corpora and the traces of the anonymous marketplaces/forums as the underground corpora. Thus, we identified 58 opioid jargon used in the anonymous marketplaces and forums (Table 2).

• This section elaborates on the methodology used to identify opioid trading information in the anonymous market and forums.
• As understanding of them improves, it is easy to see how they can benefit all stakeholders, including manufacturers, wholesalers, distributors, doctors, pharmacies, and patients.
• We evaluated our method on our annotated data set, which yields an accuracy of over 90% for each property extraction, as shown in Table 5.
• To reduce opioid-related mortality, there is a pressing need to understand the supply and demand for the product; however, no prior research that provides a greater understanding of the international opioid supply chain has been conducted.
• Any pharmacist who works in the world of specialty pharmacy knows that the specialty process is simultaneously complex and expensive.
• When a hub is operated by a pharmaceutical company, the hub can work with the pharmacy to provide patients with manufacturer co-pay assistance.
• In particular, MALLET is retrained and evaluated via 10-fold cross-validation.

Finally, we used natural language processing techniques to extract opioid trading information to characterize underground opioid commodities, suppliers, and transactions. Our research collected product listings and forum posts from 10 anonymous online market places and 6 forums. Our study determined the underground marketplace and forum list based on darknet site search engines and previous research works [20]. More specifically, we used darknet site search engines (such as Recon, Darknet live, Dark Eye, dark.fail, and DNStats [21,22]) to search underground marketplaces and forums and then manually validated their activeness.

• We are the premier platform for secure, private, Monero(XMR)-only transactions, with industry-leading security and uptime.
• Slated to open in by 2028, the project includes a new facility in Morrisville and a new site in Durham, as well as expansion of an existing Novartis facility in Durham.
• It exclusively supports XMR transactions, ensuring that all payments remain private and untraceable.
• Learn how we’re helping create safer communities and supporting people struggling with addiction and mental health issues by approving 18 new HART Hubs.
• Manufacturers are producing drugs for rare and serious conditions, often requiring limited distribution networks.
• Deaths involving fentanyl nearly doubled from the previous year’s rate in 2014, 2015, and 2016 [2].

This port, coupled with the use of both Tor and clearnet mirrors, significantly increased the attack surface for adversaries. The possibility of intercepting user data became more than a theoretical risk—it was a plausible scenario that could compromise both buyers and vendors alike. Only quality sellers who meet our standards are approved to ensure buyer safety.

Configure your Jabber client with provided credentials to receive instant alerts. The relief will be welcome in Belleville but will only be a drop in the bucket. Mayor Ellis said just over 200 people struggling with homelessness have been identified in his town, with the HART hubs likely to bring an average of 20 to 30 beds per location. Aerosols, nitrous, butane gas, and other household products – can they get you arrested?

“It may be that a person’s entire experience of using drugs has actually started through the darknet, and may indeed be confined to the darknet,” she explained. For that reason, Dr Barratt urged darknet drug users to stay diligent and exercise caution—and, wherever possible, to let someone else know what they’re going to be consuming, as well as when and where. But another worrying knock-on effect is that people who buy drugs off the darknet, rather than through a contact or a friend, may be using those drugs alone.

HUB Organoid Technology represents a paradigm shift for drug discovery and development, preclinical patient stratification, predictive diagnostics, personalized medicine, clinical trials, regenerative medicine, and companion diagnostics. HUB offers licenses to its proprietary technology and provides drug development services using its living organoid biobanks. Never access Drug Hub or any darknet marketplace without proper security precautions. Always use Tor Browser with security level set to «Safest.» Encrypt all sensitive communications with PGP. Phishing sites with similar addresses are common in the darknet ecosystem. Bookmark this clearnet page (drughub.io) and the official onion address.

Most recently, Swiss pharma behemoth Novartis unveiled plans to build a new radioligand therapy manufacturing facility in Winter Park, Florida, as part of a $23 billion U.S. investment pledge announced in April 2025. Number of monthly newly-appeared and disappeared listings in the marketplaces Agora and Evolution. To evaluate the aforementioned methods for extracting properties, we randomly chose 1000 listings for each property and manually annotated the properties as ground truth. We evaluated our method on our annotated data set, which yields an accuracy of over 90% for each property extraction, as shown in Table 5.

Check your drugs with a home testing kit or by sending them to a lab. Ketamine can provide an out-of-body experience, but be careful where, when and how you use it. You can save a life with naloxone available for free from your local drug service. Therefore, because of the advantage that the pharmaceutical manufacturer receives for the distribution of medication, they will periodically elect to operate a hub in-house. Nevertheless, this does pose challenges and it is imperative to keep patient information away from the operations of the business. A hub that operates to maintain REMS reporting requirements can provide valuable information for these reevaluations.

With its XMR-only policy, anti-DDOS protections, and secure vendor mirrors, DrugHub has solidified its position as a leading privacy-centric darknet marketplace. We employ military-grade encryption, cold storage for funds, and innovative access control mechanisms that make DDoS attacks virtually impossible. Our unique mirror distribution ensures that every user has reliable access to the marketplace at all times. Drug Hub features a unique mirror distribution system where each user receives personal mirror links. Unlike traditional marketplaces with shared backup mirrors, our system provides truly unique onion addresses for enhanced security and reliability. Advocates have broadly welcomed the HART hub funding announcements but are begging the government to reverse, or at least significantly delay, its decision to close supervised consumption sites to allow an orderly transition and avoid potentially fatal capacity problems.

Among them is Amgen, which in April announced a $900 million expansion of its Ohio manufacturing facility as part of a $1.4 billion investment plan it said has created 750 jobs. In addition, J&J kicked off 2026 by announcing plans to build a next-generation cell therapy manufacturing site in Pennsylvania. Novartis broke ground on a 700,000-square-foot flagship manufacturing hub in December. Slated to open in by 2028, the project includes a new facility in Morrisville and a new site in Durham, as well as expansion of an existing Novartis facility in Durham. The company expects to create 700 new jobs in North Carolina by 2030. Pledged projects have landed in a handful of hotspots while giving rise to potential new hubs across the U.S.

“Frost & Sullivan identifies HUB’s epithelial tissue-based technology as groundbreaking and innovative. This award recognizes HUB at the forefront of innovation and growth in the field of organoid technology, continuously improving its offerings to meet the dynamic needs of drug developers and providing state-of-the-arts solutions. As a pioneer in organoid technology, HUB offers transformative solutions to the pharmaceutical industry for more effective, faster, and ethical drug development. HUB develops disruptive PDOs that accurately replicate human drug responses compared to animal models and cell lines, greatly increasing the value and impact of drug development programs. Our team of seasoned analysts and researchers combines advanced methodologies, reliable data sources, and cutting-edge tools to produce detailed market reports, customized consulting solutions, and strategic recommendations.

Rising awareness about cancer symptoms and early detection programs are crucial factors. The government’s focus on expanding cancer treatment centers and facilitating access to modern therapeutics are fostering market development. The presence of international pharmaceutical companies and ongoing research collaborations further enhance treatment options. As the healthcare system continues to evolve, Sri Lanka is positioning itself as a key player in regional cancer management, with an emphasis on innovative therapies and patient-centric care models.

It’s part of a bigger $1.2 billion investment in advanced manufacturing facilities, AI and advanced digital technologies that will also include new capabilities. With its business-friendly environment and Texas Medical Center’s biomanufacturing project, TMC BioPort, the state proved an attractive investment location for other companies in 2025, too. Novartis plans to build two new radioligand therapy manufacturing facilities in Florida and Texas, and in October, the U.K.’s AstraZeneca opened an expanded manufacturing facility in Coppell to double the production of its high blood potassium treatment, Lokelma. Everything’s bigger in Texas, the saying goes, and that’s true of Eli Lilly’s plans to build a new $6.5 billion manufacturing facility in Houston, marking one of the state’s biggest life sciences investments. Lilly expects the project will bring 615 high-wage jobs for engineers, scientists, operations personnel and lab technicians, as well as 4,000 additional jobs during construction. The facility is also significant because it will manufacture Lilly’s highly-anticipated oral GLP-1, which is expected to receive approval in March.

To the best of our knowledge, a comprehensive overview of the opioid supply chain in the anonymous online marketplaces and forums, as well as a measurement study of trading activities, is still an open research challenge. This is the first study to measure and characterize opioid trading in anonymous online marketplaces and forums. From our measurement, we concluded that anonymous online marketplaces and forums provided easy-access platforms for global opioid supply. This paper seeks to complement current studies widening the understanding of opioid supply chains in underground marketplaces using comprehensive, large-scale, longitudinal anonymous marketplace and forum data. To this end, we propose a series of techniques to collect data; identify opioid jargon terms used in the anonymous marketplaces and forums; and profile the opioid commodities, suppliers, and transactions.